a quick look at obesity; the enemy within

obesity with an increasing prevalence rate worldwide is correlated with multiple comorbidities. unfortunately, the currently available therapies such as the pharmacotherapy, bariatric surgery or gene-transfer technology are associated with a number of disadvantages including undesirable side effects, poor compliance or transient effectiveness. therefore, modifications of the lifestyle factors might be of great importance. recently, neurotrophic factors and their metabotrophic potential in targeted pharmacology against obesity has been the focus of intense research. meanwhile, because of the complexity and multi-factorial nature of obesity, it will still remain as a challenging medical problem.